Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J. and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98(2), pp. 643-652. (doi: 10.1210/jc.2012-3481)
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Abstract
Context: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). Hypothesis: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. Design: Women (n = 55) of body mass index of 18–46 kg/m2 were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. Setting: Women were recruited at hospital antenatal appointments, and study visits were in a clinical research suite. Outcome Measures: Plasma concentrations of lipids, triglyceride-rich lipoproteins, lipoprotein lipase mass, estradiol, steroid hormone binding globulin, insulin, glucose, leptin, and adiponectin were determined. Results: Obese women commenced pregnancy with higher plasma triglyceride, reached the same maximum, and then returned to higher postnatal levels than normal-weight women. Estradiol response to pregnancy (trimester 1–3 incremental area under the curve) was positively associated with plasma triglyceride response (r2 adjusted 25%, P < .001). In the third trimester, the proportion of small, dense LDL was 2-fold higher in obese women than normal-weight women [mean (SD) 40.7 (18.8) vs 21.9 (10.9)%, P = .014], and 35% of obese, 14% of overweight, and none of the normal-weight women displayed an atherogenic LDL subfraction phenotype. The small, dense LDL mass response to pregnancy was inversely associated with adiponectin response (17%, P = .013). Conclusions: Maternal obesity is associated with an atherogenic LDL subfraction phenotype and may provide a mechanistic link to poor vascular function and adverse pregnancy outcome.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Meyer, Ms Barbara and Cooney, Mrs Josephine and Freeman, Dr Dilys and Brown, Mrs Elizabeth and Ramsay, Dr Jane and Caslake, Professor Muriel |
| Authors: | Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J., and Freeman, D.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Journal of Clinical Endocrinology and Metabolism |
| Publisher: | Endocrine Society |
| ISSN: | 0021-972X |
| ISSN (Online): | 1945-7197 |
| Published Online: | 21 January 2013 |
| Copyright Holders: | Copyright © 2013 The Endocrine Society |
| First Published: | First published in Journal of Clinical Endocrinology and Metabolism 98(2):643-652 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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