Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep

Hombach-Klonisch, S. et al. (2013) Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep. Molecular and Cellular Endocrinology, 367(1-2), pp. 98-108. (doi:10.1016/j.mce.2012.12.022)

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Abstract

<p>Ewes were exposed to sewage sludge-fertilized pastures in a study designed investigate pre-conceptual and/or gestational exposure to environmental chemicals. The in utero impact on fetal thyroid morphology and function at day 110 (of 145) of pregnancy was then determined.</p> <p>Pre-conceptual exposure increased the relative thyroid organ weights in male fetuses. The number of thyroid follicles in thyroids of fetuses after pre-conceptual or gestational exposure was reduced. This correlated with an increase in Ki67 positive cells. Pre-conceptual exposure to sewage sludge reduced small blood vessels in fetal thyroids. Thyroid tissues of exposed fetuses contained regions where mature angio-follicular units were reduced exhibiting decreased immunostaining for sodium-iodide symporter (NIS). Fetal plasma levels of fT3 and fT4 in exposed animals, however, were not different from controls suggesting compensatory changes in the thyroid gland to maintain homeostasis in exposed fetuses. The regional aberrations in thyroid morphology may impact on the post-natal life of the exposed offspring.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bellingham, Dr Michelle and Evans, Professor Neil
Authors: Hombach-Klonisch, S., Danescu, A., Begum, F., Amezaga, M.R., Rhind, S.M., Sharpe, R.M., Evans, N.P., Bellingham, M., Cotinot, C., Mandon-Pepin, B., Fowler, P.A., and Klonisch, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Molecular and Cellular Endocrinology
ISSN:0303-7207
Published Online:04 January 2013

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