Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model

Watt, J., Kennedy, S. , McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M. and Oldroyd, K.G. (2013) Succinobucol-eluting stents increase neointimal thickening and peri-strut inflammation in a porcine coronary model. Catheterization and Cardiovascular Interventions, 81(4), pp. 698-708. (doi: 10.1002/ccd.24473)

Abstract

<p>Objective: The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Background: Current drugs and polymers used to coat coronary stents remain suboptimal in terms of long term efficacy and safety. Succinobucol is a novel derivative of probucol with improved antioxidant and anti-inflammatory properties.</p> <p>Methods: Polymer-free Yukon stents were coated with 1% succinobucol (SucES), 2% rapamycin (RES), or 1% succinobucol plus 2% rapamycin solutions (SucRES) and compared with a bare metal stent (BMS).</p> <p>Results: The in vivo release profile of SucES indicated drug release up to 28 days (60% drug released at 7 days); 41 stents (BMS, n = 11; SucES, n =10; RES, n = 10; SucRES, n = 10) were implanted in the coronary arteries of 17 pigs. After 28 days, mean neointimal thickness was 0.31 ± 0.14 mm for BMS, 0.51 ± 0.14 mm for SucES, 0.19 ± 0.11 mm for RES, and 0.36 ± 0.17 mm for SucRES (P < 0.05 for SucES vs. BMS). SucES increased inflammation and fibrin deposition compared with BMS (P < 0.05), whereas RES reduced inflammation compared with BMS (P < 0.05).</p> <p>Conclusion: In this model, stent-based delivery of 1% succinobucol using a polymer-free stent platform increased neointimal formation and inflammation following coronary stenting.</p>

• Item Type: Articles
• Additional Information: The definitive version is available at www3.interscience.wiley.com
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kennedy, Professor Simon
• Authors: Watt, J., Kennedy, S., McCormick, C., Agbani, E.O., McPhaden, A., Mullen, A., Czudaj, P., Behnisch, B., Wadsworth, R.M., and Oldroyd, K.G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Catheterization and Cardiovascular Interventions
• Publisher: Wiley
• ISSN: 1522-1946
• ISSN (Online): 1522-726X
• Published Online: 14 May 2012
• Copyright Holders: Copyright © 2012 Wiley
• First Published: First published in Catheterization and Cardiovascular Interventions 81(4):698-708
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher