The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer

Mukherjee, R., Edwards, J., Underwood, M.A. and Bartlett, J.M.S. (2005) The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer. BJU International, 96(1), pp. 62-66. (doi: 10.1111/j.1464-410X.2005.05568.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1464-410X.2005.05568.x

Abstract

<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression. <b>PATIENTS AND METHODS</b>: Angiogenesis was assessed in 105 patients with either prostate cancer (79) or benign prostatic hyperplasia (BPH, 26) and these data correlated with levels of COX-2 expression in the same dataset. The mean microvessel density (MVD) was analysed as a marker of angiogenesis, using the endothelial antigen CD34 stained by immunohistochemistry. <b>RESULTS</b>: There was no difference in MVD in progressive tumour stages compared with BPH. There was a negative correlation between MVD and COX-2 expression, but the effect of increased COX-2 expression on MVD was not marked. <b>CONCLUSION</b>: These data suggest that COX-2 drives tumour spread in prostate cancer by means other than the promotion of angiogenesis.

Item Type:Articles
Additional Information:The definitive version is available at www.blackwell-synergy.com
Keywords:Prostate cancer, angiogenesis, COX-2
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Edwards, Professor Joanne
Authors: Mukherjee, R., Edwards, J., Underwood, M.A., and Bartlett, J.M.S.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:BJU International
Journal Abbr.:BJU Int.
Publisher:Wiley-Blackwell
ISSN:1464-4096
ISSN (Online):1464-410X
Published Online:17 June 2005
Copyright Holders:Copyright © 2005 Wiley-Blackwell
First Published:First published in British Journal of Urology International 96(1):62-66
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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