Raf-1 expression may influence progression to androgen insensitive prostate cancer

Mukherjee, R., Bartlett, J.M.S., Krishna, N.S., Underwood, M.A. and Edwards, J. (2005) Raf-1 expression may influence progression to androgen insensitive prostate cancer. Prostate, 64(1), pp. 101-107. (doi: 10.1002/pros.20211)

Abstract

<b>BACKGROUND</b>: Recent evidence has implicated the MAP kinase pathway with the development of androgen insensitive prostate cancer (AIPC). We have previously reported gene amplification of critical members of this pathway with the development of androgen insensitive disease. <b>METHODS</b>: Protein expression of Raf-1 was analyzed using immunohistochemistry (IHC) in a database of 65 paired tumor specimens obtained before and after the development of AIPC and correlated with other members of the pathway. <b>RESULTS</b>: Patients whose Raf-1 expression rose with development of AIPC had a significantly shorter median time to biochemical relapse compared to those whose expression fell or remained unchanged (1.16 vs. 2.62 years, <i>P</i> = 0.0005). In AIPC tumors, expression of Raf-1 correlated significantly with expression of HER2 and with expression of c-fos. <b>CONCLUSIONS</b>: We conclude that the HER2/Raf-1/AP-1 axis may promote the development of AIPC, leading to early relapse. Members of the pathway may act as novel therapeutic targets for patients.

• Item Type: Articles
• Keywords: Hormone escaped prostate cancer, HER2, MAP kinase pathway, AP-1
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Edwards, Professor Joanne
• Authors: Mukherjee, R., Bartlett, J.M.S., Krishna, N.S., Underwood, M.A., and Edwards, J.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Prostate
• ISSN: 0270-4137
• ISSN (Online): 1097-0045
• Published Online: 21 January 2005