Effect of maintenance immunosuppressive drugs on virus pathobiology: evidence and potential mechanisms

Brennan, D.C., Aguado, J.M., Potena, L., Jardine, A.G. , Legendre, C., Säemann, M.D., Mueller, N.J., Merville, P., Emery, V. and Nashan, B. (2013) Effect of maintenance immunosuppressive drugs on virus pathobiology: evidence and potential mechanisms. Reviews in Medical Virology, 23(2), pp. 97-125. (doi: 10.1002/rmv.1733)

Full text not currently available from Enlighten.

Abstract

Recent evidence suggesting a potential anti-CMV effect of mTORis is of great interest to the transplant community. However, the concept of an immunosuppressant with antiviral properties is not new, with many accounts of the antiviral properties of several agents over the years. Despite these reports, to date, there has been little effort to collate the evidence into a fuller picture. This manuscript was developed to gather the evidence of antiviral activity of the agents that comprise a typical immunosuppressive regimen against viruses that commonly reactivate following transplant (HHV1 and 2, VZV, EBV, CMV and HHV6, 7, and 8, HCV, HBV, BKV, HIV, HPV, and parvovirus). Appropriate immunosuppressive regimens posttransplant that avoid acute rejection while reducing risk of viral reactivation are also reviewed. The existing literature was disparate in nature, although indicating a possible stimulatory effect of tacrolimus on BKV, potentiation of viral reactivation by steroids, and a potential advantage of mammalian target of rapamycin (mTOR) inhibition in several viral infections, including BKV, HPV, and several herpesviruses.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jardine, Professor Alan
Authors: Brennan, D.C., Aguado, J.M., Potena, L., Jardine, A.G., Legendre, C., Säemann, M.D., Mueller, N.J., Merville, P., Emery, V., and Nashan, B.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Reviews in Medical Virology
Publisher:John Wiley & Sons Ltd.
ISSN:1052-9276
Published Online:20 November 2012

University Staff: Request a correction | Enlighten Editors: Update this record