Clark, S. , Guang, Y. and Osnowski, A. (2013) Synthesis of the C‑18-C-34 fragment of amphidinolides C, C2, and C3. Organic Letters, 15(7), pp. 1464-1467. (doi: 10.1021/ol400482j)
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Abstract
The C-18-C-34 fragment of amphidinolides C, C2, and C3 and the C-18-C-29 fragment of amphidinolide F have been constructed from a trans-2,5-disubstituted dihydrofuran. This key intermediate was prepared from a dihydrofuranone formed by diastereoselective rearrangement of a free or metal-bound oxonium ylide generated from a metal carbenoid. The side chains found in amphidinolides C and F were introduced using Sonogashira coupling reactions
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen |
Authors: | Clark, S., Guang, Y., and Osnowski, A. |
Subjects: | Q Science > QD Chemistry |
College/School: | College of Science and Engineering > School of Chemistry |
Research Group: | Clark Research Group |
Journal Name: | Organic Letters |
Journal Abbr.: | Org. Lett. |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
ISSN (Online): | 1523-7052 |
Published Online: | 25 March 2013 |
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