Synthesis of the C‑1-C-17 fragment of amphidinolides C, C2, C3, and F

Clark, S. , Yang, G. and Osnowski, A. (2013) Synthesis of the C‑1-C-17 fragment of amphidinolides C, C2, C3, and F. Organic Letters, 15(7), pp. 1460-1463. (doi:10.1021/ol4004838)

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Abstract

The C-1-C-17 fragment of amphidinolides C, C2, C3, and F has been constructed from a trans-2,5-disubstituted dihydrofuranone prepared by diastereoselective rearrangement of a free or metal-bound oxonium ylide generated from a metal carbenoid. The dihydrofuranone was converted into an aldehyde corresponding to the C-1-C-8 framework, and this was coupled to the C-9-C-17 unit by nucleophilic addition of a vinylic anion

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Clark, Professor Stephen
Authors: Clark, S., Yang, G., and Osnowski, A.
Subjects:Q Science > QD Chemistry
College/School:College of Science and Engineering > School of Chemistry
Research Group:Clark Research Group
Journal Name:Organic Letters
Journal Abbr.:Org. Lett.
ISSN:1523-7060
ISSN (Online):1523-7052
Published Online:25 March 2013
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