TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica

Barr, T.A., Brown, S., Mastroeni, P. and Gray, D. (2010) TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica. Journal of Immunology, 185(5), pp. 2783-2789. (doi:10.4049/jimmunol.1001431)

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Abstract

Protective Th1 responses to Salmonella enterica do not develop in the absence of B cells. Using chimeric mice, we dissect the early (innate) and late (cognate) contributions of B cells to Th programming. B cell-intrinsic MyD88 signaling is required for primary effector Th1 development, whereas Ag-specific BCR-mediated Ag presentation is necessary for the development of memory Th1 populations. Programming of the primary T cell response is BCR/B cell MHC II independent, but requires MyD88-dependent secretion of cytokines by B cells. Chimeras in which B cells lack IFN-γ or IL-6 genes make impaired Th1 or Th17 responses to Salmonella.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barr, Dr Tom
Authors: Barr, T.A., Brown, S., Mastroeni, P., and Gray, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Publisher:American Association of Immunologists
ISSN:0022-1767
Published Online:30 July 2010

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