Spender, L.C., Carter, M.J., O'Brien, D.I., Clark, L.J., Yu, J., Michalak, E.M., Happo, L., Cragg, M.S. and Inman, G.J. (2013) Transforming growth factor- directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas. Journal of Biological Chemistry, 288(7), pp. 5198-5209. (doi: 10.1074/jbc.M112.410274) (PMID:23243310) (PMCID:PMC3576124)
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Abstract
Background: TGF-β induces apoptosis in Burkitt's lymphoma cells. Results: PUMA is a direct target gene of TGF-β signaling and is required for rapid apoptosis. Conclusion: TGF-β-mediated direct induction of PUMA contributes to apoptosis in human and murine c-Myc-driven lymphomas. Significance: These studies link TGF-β signaling and transcriptional activation of PUMA, two factors with critical roles in regulating B-cell survival.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Inman, Professor Gareth and Spender, Dr Lindsay and O'Brien, Dr Darren |
| Authors: | Spender, L.C., Carter, M.J., O'Brien, D.I., Clark, L.J., Yu, J., Michalak, E.M., Happo, L., Cragg, M.S., and Inman, G.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Journal of Biological Chemistry |
| Journal Abbr.: | J Biol Chem. |
| Publisher: | American Society for Biochemistry and Molecular Biology, Inc. |
| ISSN: | 0021-9258 |
| ISSN (Online): | 1083-351X |
| Published Online: | 14 December 2012 |
| Copyright Holders: | Copyright © 2013 The Authors |
| First Published: | First published in Journal of Biological Chemistry 288: 5198-5209 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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