Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size

Oldknow, K.J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A.A., O'Shaughnessy, P.J. , Gygi, S.P., Schneyer, A.L. and Mukherjee, A. (2013) Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), pp. 1310-1320. (doi: 10.1210/en.2012-1886)

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Abstract

Follistatin-like 3 (FSTL3) is a glycoprotein that binds and inhibits the action of TGFβ ligands such as activin. The roles played by FSTL3 and activin signaling in organ development and homeostasis are not fully understood. The authors show mice deficient in FSTL3 develop markedly enlarged testes that are also delayed in their age-related regression. These FSTL3 knockout mice exhibit increased Sertoli cell numbers, allowing for increased spermatogenesis but otherwise showing normal testicular function. The data show that FSTL3 deletion leads to increased AKT signaling and SIRT1 expression in the testis. This demonstrates a cross-talk between TGFβ ligand and AKT signaling and leads to a potential mechanism for increased cellular survival and antiaging. The findings identify crucial roles for FSTL3 in limiting testis organ size and promoting age-related testicular regression.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:O'Shaughnessy, Professor Peter
Authors: Oldknow, K.J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A.A., O'Shaughnessy, P.J., Gygi, S.P., Schneyer, A.L., and Mukherjee, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Endocrinology
Publisher:Endocrine Society
ISSN:0013-7227
ISSN (Online):1945-7170
Published Online:13 February 2013
Copyright Holders:Copyright © 2013 The Endocrine Society
First Published:First published in Endocrinology 154(3):1310-1320
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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