Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats

Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P. and Touyz, R.M. (1995) Endothelin-1 gene expression and vascular hypertrophy in DOCA-salt hypertension compared to spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology, 22(s1), S188-S190. (doi: 10.1111/j.1440-1681.1995.tb02875.x)

Full text not currently available from Enlighten.

Abstract

<p>1. Enhanced endothelin-1 gene expression has been found in blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. In this study, the effects of salt, DOCA and the development of hypertension in DOCA-salt hypertensive rats on the expression of the endothelin-1 gene in blood vessels and on vascular hypertrophy were compared in Sprague-Dawley (SD) rats and spontaneously hypertensive rats (SHR).</p> <p>2. Increased endothelin-1 mRNA was found by northern blot analysis in the mesenteric arterial bed of DOCA-salt hypertensive rats and DOCA-salt SHR, but not in DOCA or salt-treated SD rats or in SHR, even when blood pressure reached a mean of 211 mmHg in DOCA-treated SHR.</p> <p>3. Vascular structure was studied in small mesenteric arteries mounted on a wire myograph. The media width to lumen diameter ratio showed a close correlation with systolic blood pressure except in DOCA-salt hypertensive rats and DOCA-salt SHR, in which it was greater than accounted for by the level of blood pressure. Treatment of DOCA-salt hypertensive rats with the combined ETA/ETB endothelin antagonist bosentan lowered blood pressure slightly, but vascular hypertrophy regressed almost completely and any hypertrophy remaining could be explained by the residual elevated blood pressure.</p> <p>4. In conclusion, SHR do not exhibit enhanced expression of endothelin-1 in blood vessels. DOCA, salt and elevated blood pressure interact to induce increased arterial expression of endothelin-1. Vascular overexpression of the endothelin-1 gene may produce vascular hypertrophy independently of blood pressure elevation.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Touyz, Professor Rhian
Authors: Schiffrin, E.L., Larivière, R., Li, J.S., Sventek, P., and Touyz, R.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Clinical and Experimental Pharmacology and Physiology
ISSN:0305-1870
ISSN (Online):1440-1681
Published Online:28 June 2007

University Staff: Request a correction | Enlighten Editors: Update this record