An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients

Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S. and Edwards, J. (2008) An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. Disease Markers, 24(3), pp. 157-165.

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Abstract

Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse (p=0.01) and shorter disease specific survival (p=0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p=0.02) and expression correlated with phosphorylated MAP kinase (p=0.010) and proliferation index (Ki67, p=0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade.

Item Type:Articles
Keywords:PSA, MAP kinase and proliferation
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McGlynn, Dr Liane and Edwards, Professor Joanne and McCall, Dr Pamela
Authors: Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S., and Edwards, J.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Disease Markers
Publisher:IOS Press
ISSN:0278-0240
ISSN (Online):1875-8630
Copyright Holders:Copyright © 2008 IOS Press
First Published:First published in Disease Markers 24(3):157-165
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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