An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients

Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S. and Edwards, J. (2008) An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. Disease Markers, 24(3), pp. 157-165.

Abstract

Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters. In contrast an increase in N-Ras membrane expression in the transition from hormone sensitive to hormone refractory prostate cancer was associated with shorter time to relapse (p=0.01) and shorter disease specific survival (p=0.008). In addition, patients with an increase in N-Ras membrane expression had lower levels of PSA at relapse (p=0.02) and expression correlated with phosphorylated MAP kinase (p=0.010) and proliferation index (Ki67, p=0.02). These results suggest that in a subgroup patients N-Ras expression is associated with development of hormone refractory prostate cancer via activation of the MAP kinase cascade.

• Item Type: Articles
• Keywords: PSA, MAP kinase and proliferation
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McGlynn, Dr Liane and Edwards, Professor Joanne and McCall, Dr Pamela
• Authors: Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S., and Edwards, J.
• Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Disease Markers
• Publisher: IOS Press
• ISSN: 0278-0240
• ISSN (Online): 1875-8630
• Copyright Holders: Copyright © 2008 IOS Press
• First Published: First published in Disease Markers 24(3):157-165
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.