Models of insulin signalling and longevity

Piper, M.D.W., Selman, C. , McElwee, J.J. and Partridge, L. (2005) Models of insulin signalling and longevity. Drug Discovery Today: Disease Models, 2(4), pp. 249-256. (doi: 10.1016/j.ddmod.2005.11.001)

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Abstract

Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin
Authors: Piper, M.D.W., Selman, C., McElwee, J.J., and Partridge, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Drug Discovery Today: Disease Models
ISSN:1740-6757

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