Selman, C. , Lingard, S., Gems, D., Partridge, L. and Withers, D.J. (2008) Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012b-1012b. (doi: 10.1126/science.1152366)
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Abstract
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Selman, Professor Colin |
| Authors: | Selman, C., Lingard, S., Gems, D., Partridge, L., and Withers, D.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Science |
| Publisher: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| ISSN (Online): | 1095-9203 |
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