Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis"

Selman, C. , Lingard, S., Gems, D., Partridge, L. and Withers, D.J. (2008) Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012b-1012b. (doi: 10.1126/science.1152366)

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Abstract

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate–2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

Item Type:Articles (Other)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin
Authors: Selman, C., Lingard, S., Gems, D., Partridge, L., and Withers, D.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Science
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
ISSN (Online):1095-9203

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