Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1

Selman, C. , Partridge, L. and Withers, D.J. (2011) Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS ONE, 6(1), e16144. (doi: 10.1371/journal.pone.0016144)

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Abstract

We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any effect in males might have been due to a sample size issue. While such lifespan studies are essential to our understanding of the aging process, they are generally based on survival curves derived from single experiments, primarily due to time and economic constraints. Consequently, the robustness of such findings as a basis for further investigation has been questioned. We have therefore measured lifespan in a second, separate cohort of Irs1 null female mice, and show that, consistent with our previous finding, global deletion of Irs1 significantly extends lifespan in female mice. In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. Therefore, we show that reduced IRS1-dependent signalling is a robust mechanism through which mammalian lifespan can be modulated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Selman, Professor Colin
Authors: Selman, C., Partridge, L., and Withers, D.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
Published Online:25 January 2011
Copyright Holders:Copyright © 2011 The Authors
First Published:First published in PLoS ONE 6(1):e16144
Publisher Policy:Reproduced under a Creative Commons License

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