Oxidative damage, ageing, and life-history evolution: where now?

Selman, C. , Blount, J.D., Nussey, D.H. and Speakman, J.R. (2012) Oxidative damage, ageing, and life-history evolution: where now? Trends in Ecology and Evolution, 27(10), pp. 570-577. (doi: 10.1016/j.tree.2012.06.006)

Abstract

The idea that resources are limited and animals can maximise fitness by trading costly activities off against one another forms the basis of life-history theory. Although investment in reproduction or growth negatively affects survival, the mechanisms underlying such trade-offs remain obscure. One plausible mechanism is oxidative damage to proteins, lipids, and nucleic acids caused by reactive oxygen species (ROS). Here, we critically evaluate the premise that ROS-induced oxidative damage shapes life history, focussing on birds and mammals, and highlight the importance of ecological studies examining free-living animals within this experimental framework. We conclude by emphasising the value of using multiple assays to determine oxidative protection and damage. We also highlight the importance of using standardised and appropriate protocols, and discuss future research directions.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Selman, Professor Colin
• Authors: Selman, C., Blount, J.D., Nussey, D.H., and Speakman, J.R.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Trends in Ecology and Evolution
• ISSN: 0169-5347
• ISSN (Online): 1872-8383