Material-driven fibronectin fibrillogenesis

Cantini, M. , Gonzalez-Garcia, C., Llopis-Hernández, V. and Salmerón-Sánchez, M. (2012) Material-driven fibronectin fibrillogenesis. In: Horbett, T., Brash, B. and Norde, N. (eds.) Proteins at Interfaces III State of the Art 2012. Series: ACS symposium series (1120). American Chemical Society: Washington DC, VA, USA, pp. 471-496. (doi:10.1021/bk-2012-1120.ch022)

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Publisher's URL: http://dx.doi.org/10.1021/bk-2012-1120.ch022

Abstract

Material-driven fibronectin fibrillogenesis is a novel route to engineer the network structure and biological activity of fibronectin fibrillar matrices in analogy with their physiological cell-mediated assembly. We identify specific surface chemistries that promote the cell-free formation of physiological-like fibronectin fibrils in a time- and concentration-dependent process. Our most recent and relevant results, reviewed in the chapter, demonstrate the role of this material-induced fibrillogenesis in cell adhesion, extracellular matrix organization and degradation, and cell differentiation.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Cantini, Dr Marco and Gonzalez Garcia, Dr Cristina
Authors: Cantini, M., Gonzalez-Garcia, C., Llopis-Hernández, V., and Salmerón-Sánchez, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Publisher:American Chemical Society
ISSN:0097-6156

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