Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices

Sjöström, T., Brydone, A.S., Meek, R.M.D., Dalby, M.J. , Su, B. and McNamara, L.E. (2013) Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices. Nanomedicine, 8(1), pp. 89-104. (doi:10.2217/NNM.12.177)

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Abstract

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient’s stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McNamara, Dr Laura and Dalby, Professor Matthew
Authors: Sjöström, T., Brydone, A.S., Meek, R.M.D., Dalby, M.J., Su, B., and McNamara, L.E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Nanomedicine
ISSN:1743-5889
ISSN (Online):1748-6963

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