Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer

Roxburgh, C.S.D. , Wallace, A.M., Guthrie, G., Horgan, P.G. and McMillan, D.C. (2010) Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer. Colorectal Disease, 12(10), pp. 987-994. (doi:10.1111/j.1463-1318.2009.01961.x) (PMID:19555389)

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Abstract

<b>Aim</b>: To comprehensively compare the prognostic value of tumour and patient-related factors in patients undergoing curative surgery for colon cancer. <b>Methods</b>: From a database of 287 patients who underwent elective resection between 1997-2005, tumour factors including stage and host factors including systemic inflammatory response (modified Glasgow Prognostic Score (mGPS)) were identified. <b>Results</b>: Median follow-up was 65 months. Over this time period 125 patients died, 80 from cancer. On multivariate analysis of all significant patient and tumour related factors, Dukes stage (P<0.01), vascular invasion (P<0.01), and the mGPS (P<0.01) were independently associated with cancer-survival. Of the patient-related factors, age (P<0.01), haemoglobin (P<0.01), white-cell (P<0.01), neutrophil (P<0.01) and platelet (P<0.01) counts and alkaline phosphatase (P<0.01) were most significantly associated with the mGPS. <b>Conclusion</b>: In addition to tumour-related factors such as Dukes stage and vascular invasion, the pre-operative mGPS should be included to guide prognosis in patients undergoing curative resection for colon cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Guthrie, Dr Graeme and Horgan, Professor Paul and McMillan, Professor Donald and Roxburgh, Dr Campbell
Authors: Roxburgh, C.S.D., Wallace, A.M., Guthrie, G., Horgan, P.G., and McMillan, D.C.
Subjects:R Medicine > RD Surgery
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Colorectal Disease
Publisher:Wiley on behalf of The Association of Coloproctology of Great Britain and Ireland
ISSN:1462-8910
ISSN (Online):1463-1318
Published Online:25 June 2009
Copyright Holders:Copyright © 2010 The Association of Coloproctology of Great Britain and Ireland
First Published:First published in Colorectal Disease 12(10):987-994
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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