Mast cells and vascular diseases

Kennedy, S. , Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi:10.1016/j.pharmthera.2013.01.001)

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Abstract

Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while mast cell-derived mediators such as cytokines and chemokines can perpetuate vascular inflammation. Mice lacking mast cells have been developed and these are providing an insight into how mast cells are involved in cardiovascular diseases and, as knowledge increase, mast cells may become a viable therapeutic target to slow progression of cardiovascular disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maffia, Dr Pasquale and Lawrence, Dr Catherine and Kennedy, Dr Simon
Authors: Kennedy, S., Wu, J., Wadsworth, R.M., Lawrence, C.E., and Maffia, P.
Subjects:Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Pharmacology and Therapeutics
ISSN:0163-7258
Published Online:16 January 2013

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