Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53

Finlay, M., Yuan, Z., Morgan, I.M., Campo, M. and Nasir, L. (2012) Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53. Veterinary Research, 43, p. 81. (doi: 10.1186/1297-9716-43-81)

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Abstract

Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours. Whilst treatment of sarcoids is notoriously difficult, cisplatin has been shown to be one of the most effective treatment strategies for sarcoids. In this study we show that in equine fibroblasts, BPV-1 sensitises cells to cisplatin-induced and UVB-induced apoptosis, a known cofactor for papillomavirus associated disease, however BPV-1 transformed fibroblasts show increased clonogenic survival, which may potentially limit the therapeutic effects of repeated cisplatin treatment. Furthermore we show that BPV-1 increases p53 expression in sarcoid cell lines and p53 expression can be either nuclear or cytoplasmic. The mechanism and clinical significance of increase/abnormal p53 expression remains to be established.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Finlay, Ms Margaret and Nasir, Professor Lubna and Morgan, Professor Iain and Yuan, Dr Zhengqiang
Authors: Finlay, M., Yuan, Z., Morgan, I.M., Campo, M., and Nasir, L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Research
Publisher:BioMed Central Ltd.
ISSN:0928-4249
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Veterinary Research 43:81
Publisher Policy:Reproduced under a Creative Commons License

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