Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer

Roxburgh, C.S.D., Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G. and McMillan, D.C. (2009) Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer. British Journal of Cancer, 100(5), pp. 701-706. (doi:10.1038/sj.bjc.6604926)

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Publisher's URL: http://dx.doi.org/10.1038/sj.bjc.6604926

Abstract

After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and C disease. Similarly, the modified Glasgow Prognostic Score (mGPS) based on biochemical criteria has also been validated. This study compares both the scores in patients undergoing curative resection of colon cancer. A total of 244 patients underwent elective resection between 1997 and 2005. The PI was constructed from pathological reports; the mGPS was measured pre-operatively. The median follow-up was 67 months (minimum 36 months) during which 109 patients died; 68 of them from cancer. On multivariate analysis of age, Dukes' stage, PI and mGPS, age (hazard ratio, HR, 1.74, P=0.001), Dukes' stage (HR, 3.63, P<0.001), PI (HR, 2.05, P=0.010) and mGPS (HR, 2.34, P<0.001) were associated independently with cancer-specific survival. Three-year cancer-specific survival rates for Dukes' B patients with the low-risk PI were 98, 92 and 82% for the mGPS of 0, 1 and 2, respectively (P<0.05). The high-risk PI population is small, in particular for Dukes' B disease (9%). The mGPS further stratifies those patients classified as low risk by the PI. Combining both the scoring systems could identify patients who have undergone curative surgery but are at high-risk of cancer-related death, therefore guiding management and trial stratification.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald and Roxburgh, Dr Campbell
Authors: Roxburgh, C.S.D., Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G., and McMillan, D.C.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:British Journal of Cancer
Journal Abbr.:Br J Cancer
Publisher:Nature Publishing Group
ISSN:0007-0920
Published Online:10 February 2009
Copyright Holders:Copyright © 2009 Nature Publishing Group
First Published:First published in British Journal of Cancer 100(5):701-706
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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