Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

Cantini, M. , Rico, P., Moratal, D. and Salmerón-Sánchez, M. (2012) Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings. Soft Matter, 8(20), pp. 5575-5584. (doi: 10.1039/c2sm25413a)

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Plasma polymerization was used to produce novel nanometric coatings able to direct fibronectin adsorption and cell response. Using ethyl acrylate as a monomer, we obtain coatings whose chemical composition maintains some of the characteristic functionalities of the photo-initiated polymer, while the water contact angle increases monotonically with the duration of the plasma discharge. Enhanced surface mobility of the polymer chains due to a decrease of the thickness of the coating justifies this increase in wettability at lower treatment times. The coatings with higher surface mobility are shown to promote a more active conformation of the adsorbed protein, as proved by binding of the monoclonal antibodies HFN7.1 and mAb1937. Culture of MC3T3-E1 osteoblast-like cells onto the fibronectin-coated substrates further proves that the more mobile surfaces support better initial cell adhesion, even at low fibronectin surface density, as well as stronger cell-mediated fibronectin reorganization.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Cantini, Dr Marco
Authors: Cantini, M., Rico, P., Moratal, D., and Salmerón-Sánchez, M.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Soft Matter
Publisher:Royal Society of Chemistry
ISSN (Online):1744-6848
Published Online:13 April 2012

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