Observing micro-evolutionary processes of viral populations at multiple scales

Orton, R.J. , Wright, C.F., Morelli, M.J., Juleff, N., Thebaud, G., Knowles, N.J., Valdazo-Gonzalez, B., Paton, D.J., King, D.P. and Haydon, D.T. (2013) Observing micro-evolutionary processes of viral populations at multiple scales. Philosophical Transactions of the Royal Society B: Biological Sciences, 368(1614), (doi:10.1098/rstb.2012.0203)

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Abstract

Advances in sequencing technology coupled with new integrative approaches to data analysis provide a potentially transformative opportunity to use pathogen genome data to advance our understanding of transmission. However, to maximize the insights such genetic data can provide, we need to understand more about how the microevolution of pathogens is observed at different scales of biological organization. Here, we examine the evolutionary processes in foot-and-mouth disease virus observed at different scales, ranging from the tissue, animal, herd and region. At each scale, we observe analogous processes of population expansion, mutation and selection resulting in the accumulation of mutations over increasing time scales. While the current data are limited, rates of nucleotide substitution appear to be faster over individual-to-individual transmission events compared with those observed at a within-individual scale suggesting that viral population bottlenecks between individuals facilitate the fixation of polymorphisms. Longer-term rates of nucleotide substitution were found to be equivalent in individual-to-individual transmission compared with herd-to-herd transmission indicating that viral diversification at the herd level is not retained at a regional scale.

Item Type:Articles
Keywords:Virus, evolution, scales, foot-and-mouth disease, transmission, bottlenecks
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Haydon, Professor Daniel and Thebaud, Dr Gael and Orton, Dr Richard and Morelli, Dr Marco
Authors: Orton, R.J., Wright, C.F., Morelli, M.J., Juleff, N., Thebaud, G., Knowles, N.J., Valdazo-Gonzalez, B., Paton, D.J., King, D.P., and Haydon, D.T.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8436
ISSN (Online):1471-2970
Published Online:04 February 2013
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Philosophical Transactions of the Royal Society B: Biological Sciences 368(1614)
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
548301Beyond the consensus: defining the significance of foot and mouth disease viral sequence diversityDaniel HaydonBiotechnology and Biological Sciences Research Council (BBSRC)BB/I013784/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED
461341A systems biology approach to integrating pathogen evolution and epidemiologyDaniel HaydonBiotechnology and Biological Sciences Research Council (BBSRC)BB/F005733/1RI BIODIVERSITY ANIMAL HEALTH & COMPMED
443881Population genetics and genomics of ovine parasitic nematodes and their application to the study of anthelmintic resistanceAndrew TaitBiotechnology and Biological Sciences Research Council (BBSRC)BB/E018505/1SCHOOL OF VETERINARY MEDICINE