An MRI-histological study of white matter in stroke-free SHRSP

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi: 10.1038/jcbfm.2013.14)

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Hypertension is associated with cerebral small vessel disease (SVD) and with diffuse white matter hyperintensities (WMH) on T<sub>2</sub>-weighted magnetic resonance imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) without stroke symptoms were compared with age-matched male WKY rats. Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T<sub>2</sub>, T<sub>2</sub>*, diffusion tensor imaging) and no neuropathological lesions. While leptomeningeal arteries exhibited fibrohyaline wall thickening, with decreased smooth muscle actin relative to WKY, deep penetrating arterioles within the caudate nuclei had no vasculopathy. We conclude that WMH are not an obligate feature of stroke-free SHRSP aged up to 10 months.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Macrae, Professor Mhairi and Graham, Dr Delyth and Holmes, Dr William and Dominiczak, Professor Anna and McCabe, Dr Chris
Authors: Brittain, J.F., McCabe, C., Khatun, H., Kaushal, N., Bridges, L.R., Holmes, W.M., Barrick, T.R., Graham, D., Dominiczak, A.F., Macrae, I. M., and Hainsworth, A.H.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Journal of Cerebral Blood Flow and Metabolism
Journal Abbr.:J. Cereb. Blood Flow Metab.
Publisher:Nature Publishing Group
ISSN (Online):1559-7016
Published Online:13 February 2013

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