Crossed cerebellar diaschisis: insights into oxygen challenge MRI

Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M. and Muir, K.W. (2012) Crossed cerebellar diaschisis: insights into oxygen challenge MRI. Journal of Cerebral Blood Flow and Metabolism, 32(12), pp. 2114-2117. (doi: 10.1038/jcbfm.2012.142)

Abstract

Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Brennan, Dr David and Santosh, Dr Celestine and Muir, Professor Keith and Hadley, Professor Donald and Dani, Dr Krishna
• Authors: Dani, K.A., Santosh, C., Brennan, D., Hadley, D.M., and Muir, K.W.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Cerebral Blood Flow and Metabolism
• Publisher: Nature Publishing Group
• ISSN: 0271-678X
• ISSN (Online): 1559-7016