GPCR theme editorial

Milligan, G. and McGrath, J.C. (2009) GPCR theme editorial. British Journal of Pharmacology, 158(1), pp. 1-4. (doi: 10.1111/j.1476-5381.2009.00422.x)

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This themed section of BJP includes 11 reviews on the biology of G-protein coupled receptors (GPCRs) and the drug targets that these present, 21 research papers on the pharmacology of a range of GPCRs and commentaries on four of the papers. Areas reviewed include molecular interactions, particular in respect of hetero-dimerisation between receptors and other membrane-located proteins and other key signalling molecules including cAMP and G12/13 proteins and recently de-orphanised receptors including the Neuromedins U and S and the Free Fatty Acid receptors FFA2 and FFA3. The research papers cover the pharmacology of a range of agents acting at GPCRs, including adrenoceptors, purinoceptors, 5HT, opioid, cannabinoid and PAR-2 receptors. A group of papers is concerned with the interesting and rapidly developing pharmacology of drugs acting at β2-adrenoceptors. The reach of GPCRs is illustrated by the range of physiological systems and therapeutic applications involved, including pain, cancer, cardiovascular, gastrointestinal, visual and respiratory and central nervous systems.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McGrath, Professor John and Milligan, Professor Graeme
Authors: Milligan, G., and McGrath, J.C.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:British Journal of Pharmacology
Journal Abbr.:Brit J Pharmacol
Published Online:25 August 2009

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