What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

McCulloch, R. and Horn, D. (2009) What has DNA sequencing revealed about the VSG expression sites of African trypanosomes? Trends in Parasitology, 25(8), pp. 359-363. (doi: 10.1016/j.pt.2009.05.007)

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Publisher's URL: http://dx.doi.org/10.1016/j.pt.2009.05.007


Antigenic variation is crucial for the survival of African trypanosomes in mammals and involves switches in expression of variant surface glycoprotein genes, which are co-transcribed with a number of expression-site-associated genes (<i>ESAG</i>s) from loci termed 'blood-stream expression sites' (BESs). Trypanosomes possess multiple BESs, although the reason for this (and why <i>ESAG</i>s are resident in these loci) has remained a subject of debate. The genome sequence of <i>Trypanosoma brucei</i>, released in 2005, did not include the BESs because of their telomeric disposition. This gap in our knowledge has now been bridged by two new studies, which we discuss here, asking what has been revealed about the biological significance of BES multiplicity and <i>ESAG</i> function and evolution

Item Type:Articles
Glasgow Author(s) Enlighten ID:McCulloch, Professor Richard and Horn, Mr David
Authors: McCulloch, R., and Horn, D.
Subjects:Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
ISSN (Online):1471-5007
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
401101DNA recombination pathways and antigenic variation in trypanosoma bruceiRichard McCullochMedical Research Council (MRC)G0401553Infection Immunity and Inflammation Life Sciences