Linking the antigen archive structure to pathogen fitness in African trypanosomes

Gjini, E., Haydon, D.T. , Barry, J.D. and Cobbold, C.A. (2013) Linking the antigen archive structure to pathogen fitness in African trypanosomes. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1753), p. 20122129. (doi: 10.1098/rspb.2012.2129)

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Abstract

Systems that generate antigenic variation enable pathogens to evade host immune responses and are intricately interwoven with major pathogen traits, such as host choice, growth, virulence and transmission. Although much is understood about antigen switching at the molecular level, little is known about the cross-scale links between these molecular processes and the larger-scale within and between host population dynamics that they must ultimately drive. Inspired by the antigenic variation system of African trypanosomes, we apply modelling approaches to our expanding understanding of the organization and expression of antigen repertoires, and explore links across these scales. We predict how pathogen population processes are determined by underlying molecular genetics and infer resulting selective pressures on important emergent repertoire traits.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cobbold, Professor Christina and Haydon, Professor Daniel and Gjini, Ms Erida and Barry, Professor J
Authors: Gjini, E., Haydon, D.T., Barry, J.D., and Cobbold, C.A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Proceedings of the Royal Society of London Series B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8452
Published Online:02 January 2013

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