FlyAtlas: database of gene expression in the tissues of drosophila melanogaster

Robinson, S.W., Herzyk, P. , Dow, J.A.T. and Leader, D.P. (2013) FlyAtlas: database of gene expression in the tissues of drosophila melanogaster. Nucleic Acids Research, 41(D1), D744-D750. (doi:10.1093/nar/gks1141) (PMID:23203866) (PMCID:PMC3531048)

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Abstract

The FlyAtlas resource contains data on the expression of the genes of Drosophila melanogaster in different tissues (currently 25—17 adult and 8 larval) obtained by hybridization of messenger RNA to Affymetrix Drosophila Genome 2 microarrays. The microarray probe sets cover 13 250 Drosophila genes, detecting 12 533 in an unambiguous manner. The data underlying the original web application (http://flyatlas.org) have been restructured into a relational database and a Java servlet written to provide a new web interface, FlyAtlas 2 (http://flyatlas.gla.ac.uk/), which allows several additional queries. Users can retrieve data for individual genes or for groups of genes belonging to the same or related ontological categories. Assistance in selecting valid search terms is provided by an Ajax ‘autosuggest’ facility that polls the database as the user types. Searches can also focus on particular tissues, and data can be retrieved for the most highly expressed genes, for genes of a particular category with above-average expression or for genes with the greatest difference in expression between the larval and adult stages. A novel facility allows the database to be queried with a specific gene to find other genes with a similar pattern of expression across the different tissues.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Herzyk, Dr Pawel and Dow, Professor Julian and Leader, Dr David and Robinson, Mr Scott
Authors: Robinson, S.W., Herzyk, P., Dow, J.A.T., and Leader, D.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Nucleic Acids Research
Publisher:Oxford University Press
ISSN:0305-1048
Published Online:29 November 2012
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Nucleic Acids Research 41(D1):D744-D750
Publisher Policy:Reproduced under a Creative Commons License

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