Adiposity, adipokines, and risk of incident stroke in older men

Wannamethee, S.G., Shaper, A.G., Whincup, P.H., Lennon, L. and Sattar, N. (2013) Adiposity, adipokines, and risk of incident stroke in older men. Stroke, 44(1), pp. 3-8. (doi:10.1161/STROKEAHA.112.670331)

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Abstract

Background and Purpose—The association between adiposity and adipocytes and risk of stroke in older adults is uncertain. We have examined the association between adiposity measures and adipocytes (adiponectin and leptin) with incident stroke events in older men.

Methods—Prospective study of 3411 men aged 60 to 79 years with no previous diagnosis of myocardial infarction, heart failure, or stroke followed-up for an average of 9 years, during which there were 192 incident major stroke events.

Results—In age-adjusted analyses, body mass index and waist circumference were not significantly associated with risk of stroke in older men, although obese men (body mass index >30 kg/m2) showed the lowest risk of stroke. Despite the strong positive correlation between leptin and body mass index and waist circumference, risk of stroke was significantly increased in those in the top quartile of the leptin distribution. The increased risk remained after adjustment for potential confounders, including systolic blood pressure (adjusted hazard ratios top quartile versus bottom quartile: 2.03; confidence interval, 1.27–3.27]). Further adjustment for markers of inflammation (c-reactive protein), endothelial dysfunction (von Willebrand factor), fibrinolytic activity (d-dimer), and γ-glutamyl transferase attenuated the increased risk, but risk remained significantly increased (adjusted hazard ratios, 1.73; confidence interval, 1.06–2.83]). By contrast, no association was seen between adiponectin and risk of stroke.

Conclusions—Conventional adiposity measures were not associated with increased stroke risk in older men. However, leptin (a good marker of percent fat mass), but not adiponectin, predicted stroke, suggesting a link between fat mass and stroke risk.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed
Authors: Wannamethee, S.G., Shaper, A.G., Whincup, P.H., Lennon, L., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Stroke
Publisher:American Heart Association
ISSN:0039-2499
Published Online:27 November 2012
Copyright Holders:Copyright © 2012 American Heart Association
First Published:First published in Stroke 44(1):3-8
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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