Examining the role of insulin in the regulation of cardiovascular health

Salt, I. P. (2013) Examining the role of insulin in the regulation of cardiovascular health. Future Cardiology, 9(1), pp. 39-52. (doi:10.2217/fca.12.77) (PMID:23259474)

[img]
Preview
Text
75490.pdf - Accepted Version

248kB

Abstract

A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids. In particular, insulin regulates endothelial synthesis of the vasoactive mediators nitric oxide and endothelin-1, yet the importance of this in the maintenance of cardiovascular health remains poorly understood. Recent studies using animals with targeted downregulation of insulin signaling in vascular tissues are improving our understanding of the role of insulin in vascular health. This article focuses on the direct actions of insulin in cardiovascular tissues, with particular emphasis on the molecular mechanisms of insulin action on endothelial function. The potential contribution of impaired vascular insulin action to the cardiovascular complications of diabetes will also be discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salt, Dr Ian
Authors: Salt, I. P.
Subjects:R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Future Cardiology
Publisher:Future Medicine Ltd.
ISSN:1479-6678
ISSN (Online):1744-8298
Copyright Holders:Copyright © 2013 Future Medicine Ltd.
First Published:First published in Future Cardiology 9(1):39-52
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

University Staff: Request a correction | Enlighten Editors: Update this record