Macrophage autophagy in atherosclerosis

Maiuri, M.C., Grassia, G., Platt, A., Carnuccio, R., Ialenti, A. and Maffia, P. (2013) Macrophage autophagy in atherosclerosis. Mediators of Inflammation, 2013, Art. 584715. (doi:10.1155/2013/584715)

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Abstract

Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation. AP is a cellular catabolic process involving the delivery of cytoplasmic contents to the lysosomal machinery for ultimate degradation and recycling. Basal levels of macrophage AP play an essential role in atheroprotection during early atherosclerosis. However, AP becomes dysfunctional in the more advanced stages of the pathology and its deficiency promotes vascular inflammation, oxidative stress, and plaque necrosis. In this paper, we will discuss the role of macrophages and AP in atherosclerosis and the emerging evidence demonstrating the contribution of macrophage AP to vascular pathology. Finally, we will discuss how AP could be targeted for therapeutic utility.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Platt, Dr Andrew and Maffia, Dr Pasquale and Grassia, Dr Gianluca
Authors: Maiuri, M.C., Grassia, G., Platt, A., Carnuccio, R., Ialenti, A., and Maffia, P.
Subjects:Q Science > QR Microbiology > QR180 Immunology
R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Mediators of Inflammation
Publisher:Hindawi Publishing Corporation
ISSN:0962-9351
ISSN (Online):1466-1861
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Mediators of Inflammation 2013:584715
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
524831Visualising antigen presentation in mouse models of atherosclerosisPasquale MaffiaMedical Research Scotland (MED-SCOT)276 FRGIII -IMMUNOLOGY