Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues

Al-Rawhani, M., Chitnis, D., Beeley, J., Collins, S. and Cumming, D. (2013) Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues. IEEE Transactions on Biomedical Engineering, 60(1), pp. 55-62. (doi:10.1109/TBME.2012.2222641)

Al-Rawhani, M., Chitnis, D., Beeley, J., Collins, S. and Cumming, D. (2013) Design and implementation of a wireless capsule suitable for autofluorescence intensity detection in biological tissues. IEEE Transactions on Biomedical Engineering, 60(1), pp. 55-62. (doi:10.1109/TBME.2012.2222641)

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Abstract

We report on the design, fabrication, testing, and packaging of a miniaturized system capable of detecting autofluorescence (AF) from mammalian intestinal tissue. The system comprises an application-specific integrated circuit (ASIC), light-emitting diode, optical filters, control unit, and radio transmitter. The ASIC contains a high-voltage charge pump and single-photon avalanche diode detector (SPAD). The charge pump biases the SPAD above its breakdown voltage to operate in Geiger mode. The SPAD offers a photon detection efficiency of 37% at 520 nm, which corresponds to the AF emission peak of the principle human intestinal fluorophore, flavin adenine dinucleotide. The ASIC was fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3 V and draws an average of 7.1 mA, enabling up to 23 h of continuous operation from two 165-mAh SR44 batteries.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Al-Rawhani, Dr Mohammed and Cumming, Professor David and Beeley, Mr James
Authors: Al-Rawhani, M., Chitnis, D., Beeley, J., Collins, S., and Cumming, D.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Biomedical Engineering
ISSN:0018-9294
Published Online:20 December 2012

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