Effects of dalcetrapib in patients with a recent acute coronary syndrome

Schwartz, G.G. et al. (2012) Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine, 367(22), pp. 2089-2099. (doi: 10.1056/NEJMoa1206797)

Abstract

In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes.

• Item Type: Articles
• Additional Information: From New England Journal of Medicine, Schwartz, G.G., Olsson, A.G., Abt, M., Ballantyne, C.M., Barter, P.J., Brumm, J., Chaitman, B.R., Holme, I.M., Kallend, D., Leiter, L.A., Leitersdorf, E., McMurray, J.J.V., Mundl, H., Nicholls, S.J., Shah, P.K., Tardif, J., and Wright, R.S., Effects of dalcetrapib in patients with a recent acute coronary syndrome, 367, pp. 2089-2099. Copyright © 2012 Massachusetts Medical Society. Reprinted with permission.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: Schwartz, G.G., Olsson, A.G., Abt, M., Ballantyne, C.M., Barter, P.J., Brumm, J., Chaitman, B.R., Holme, I.M., Kallend, D., Leiter, L.A., Leitersdorf, E., McMurray, J.J.V., Mundl, H., Nicholls, S.J., Shah, P.K., Tardif, J., and Wright, R.S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: New England Journal of Medicine
• Publisher: Massachusetts Medical Society
• ISSN: 0028-4793
• Published Online: 05 November 2012
• Copyright Holders: Copyright © 2012 Massachusetts Medical Society
• First Published: First published in New England Journal of Medicine 367(22):2089-2099
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher