Suppression, subversion and escape: the role of regulatory T cells in cancer progression

Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi: 10.1111/j.1365-2249.2012.04657.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2249.2012.04657.x

Abstract

Regulatory T cells (T<sub>regs</sub>) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. However, in the context of cancer their role is more complex, and they are thought to contribute to the progress of many tumours. As cancer cells express both self- and tumour-associated antigens, T<sub>regs</sub> are key to dampening effector cell responses, and therefore represent one of the main obstacles to effective anti-tumour responses. Suppression mechanisms employed by T<sub>regs</sub> are thought to contribute significantly to the failure of current therapies that rely on induction or potentiation of anti-tumour responses. This review will focus on the current evidence supporting the central role of T<sub>regs</sub> in establishing tumour-specific tolerance and promoting cancer escape. We outline the mechanisms underlying their suppressive function and discuss the potential routes of T<sub>regs</sub> accumulation within the tumour, including enhanced recruitment, in-situ or local proliferation, and de-novo differentiation. In addition, we review some of the cancer treatment strategies that act, at least in part, to eliminate or interfere with the function of T<sub>regs</sub>. The role of T<sub>regs</sub> is being recognized increasingly in cancer, and controlling the function of these suppressive cells in the tumour microenvironment without compromising peripheral tolerance represents a significant challenge for cancer therapies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fraser, Dr Alasdair and Nibbs, Professor Rob and Graham, Professor Gerard
Authors: Oleinika, K., Nibbs, R.J., Graham, G.J., and Fraser, A.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Clinical and Experimental Immunology
Publisher:Wiley-Blackwell Publishing Ltd.
ISSN:0009-9104
ISSN (Online):1365-2249
Published Online:03 December 2012
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
514422Regulation of the adaptive immune response by chemokine scavenging receptorsGerard GrahamMedical Research Council (MRC)G0901113III -IMMUNOLOGY