Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley, A. J. et al. (2012) Brucellosis among Hospitalized Febrile Patients in Northern Tanzania. American Journal of Tropical Medicine and Hygiene, 87(6), pp. 1105-1111. (doi:10.4269/ajtmh.2012.12-0327)

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Publisher's URL: http://dx.doi.org/10.4269/ajtmh.2012.12-0327

Abstract

Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a ≥ 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer ≥ 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with ≥ 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of Health and Human Services or the Centers for Disease Control and Prevention.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleaveland, Professor Sarah
Authors: Bouley, A. J., Biggs, H. M., Stoddard, R. A., Morrissey, A. B., Bartlett, J. A., Afwamba, I. A., Maro, V. P., Kinabo, G. D., Saganda, W., Cleaveland, S., and Crump, J. A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:American Journal of Tropical Medicine and Hygiene
Publisher:American Society of Tropical Medicine and Hygiene
ISSN:0002-9637
ISSN (Online):1476-1645
Published Online:22 October 2012
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
538321Rodents and bats as reservoirs of zoonoses: ecological and social determinants of human disease risk in Kenya.Sarah CleavelandMedical Research Council (MRC)G0902417RI BIODIVERSITY ANIMAL HEALTH & COMPMED