Design and process development of a photonic crystal polymer biosensor for point of care diagnostics

Johnson, N., De La Rue, R.M. , Sharp, G. and Lahiri, B. (2011) Design and process development of a photonic crystal polymer biosensor for point of care diagnostics. Proceedings of SPIE: OSA Biomedical Optics, 8087, D. (doi:10.1117/12.889420)

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Abstract

In this work, we report advances in the fabrication and anticipated performance of a polymer biosensor photonic chip developed in the European Union project P3SENS (FP7-ICT4-248304). Due to the low cost requirements of point-ofcare applications, the photonic chip is fabricated from nanocomposite polymeric materials, using highly scalable nanoimprint-lithography (NIL). A suitable microfluidic structure transporting the analyte solutions to the sensor area is alsofabricated in polymer and adequately bonded to the photonic chip. We first discuss the design and the simulated performance of a high-Q resonant cavity photonic crystal sensor made of a high refractive index polyimide core waveguide on a low index polymer cladding. We then report the advances in doped and undoped polymer thin film processing and characterization for fabricating the photonic sensor chip. Finally the development of the microfluidic chip is presented in details, including the characterisation of the fluidic behaviour, thetechnological and material aspects of the 3D polymer structuring and the stable adhesion strategies for bonding the fluidic and the photonic chips, with regards to the constraints imposed by the bioreceptors supposedly already present on the sensors.

Item Type:Articles
Additional Information:Copyright 2011 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Keywords:Lab-on-a-chip, photonic crystal, biosensor, point-of-care diagnostics, polymer, polyimide, nanocomposites, nanoimprint lithography
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sharp, Mr Graham and Johnson, Dr Nigel and Lahiri, Dr Basudev and De La Rue, Professor Richard
Authors: Johnson, N., De La Rue, R.M., Sharp, G., and Lahiri, B.
Subjects:Q Science > QC Physics
College/School:College of Arts > School of Critical Studies > Scottish Literature
Research Group:Optoectronics
Journal Name:Proceedings of SPIE: OSA Biomedical Optics
Publisher:International Society for Optical Engineering
ISSN:1996-756X
ISSN (Online):0277-786X
Copyright Holders:Copyright © 2011 SPIE - OSA
First Published:First published in Proceedings of SPIE - OSA Biomedical Optics
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
518831P3SENSNigel JohnsonEuropean Commission (EC)FP7 248304 P3SEENG - ENGINEERING ELECTRONICS & NANO ENG