Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model

Brunker, K. , Hampson, K. , Horton, D.L. and Biek, R. (2012) Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model. Parasitology, 139(14), pp. 1899-1913. (doi:10.1017/S003118201200090X)

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Publisher's URL: http://dx.doi.org/10.1017/S003118201200090X

Abstract

Landscape epidemiology and landscape genetics combine advances in molecular techniques, spatial analyses and epidemiological models to generate a more real-world understanding of infectious disease dynamics and provide powerful new tools for the study of RNA viruses. Using dog rabies as a model we have identified how key questions regarding viral spread and persistence can be addressed using a combination of these techniques. In contrast to wildlife rabies, investigations into the landscape epidemiology of domestic dog rabies requires more detailed assessment of the role of humans in disease spread, including the incorporation of anthropogenic landscape features, human movements and socio-cultural factors into spatial models. In particular, identifying and quantifying the influence of anthropogenic features on pathogen spread and measuring the permeability of dispersal barriers are important considerations for planning control strategies, and may differ according to cultural, social and geographical variation across countries or continents. Challenges for dog rabies research include the development of metapopulation models and transmission networks using genetic information to uncover potential source/sink dynamics and identify the main routes of viral dissemination. Information generated from a landscape genetics approach will facilitate spatially strategic control programmes that accommodate for heterogeneities in the landscape and therefore utilise resources in the most cost-effective way. This can include the efficient placement of vaccine barriers, surveillance points and adaptive management for large-scale control programmes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hampson, Dr Katie and Biek, Dr Roman and Brunker, Dr Kirstyn
Authors: Brunker, K., Hampson, K., Horton, D.L., and Biek, R.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Parasitology
Publisher:Cambridge University Press
ISSN:0031-1820
Published Online:20 July 2012
Copyright Holders:Copyright © 2012 Cambridge University Press
First Published:First published in Parasitology 139(14):1899-1913
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
508041Understanding how a complex intervention works: designing large-scale vaccination programsDaniel HaydonMedical Research Council (MRC)G0901135/91914RI BIODIVERSITY ANIMAL HEALTH & COMPMED