Heat shock proteins in tendinopathy: novel molecular regulators

Millar, N.L. and Murrell, G.A.C. (2012) Heat shock proteins in tendinopathy: novel molecular regulators. Mediators of Inflammation, 2012, p. 436203. (doi:10.1155/2012/436203)

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Abstract

Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations. Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and cellular load provides important mechanistic insight into the area of heat shock proteins which spans many disease processes in the autoimmune community. Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. Our investigations have highlighted a key role for HSPs in tendion disease which may ultimately affect tissue rescue mechanisms in tendon pathology. This paper aims to provide an overview of the biology of heat shock proteins in soft tissue and how these mediators may be important regulators of inflammatory mediators and matrix regulation in tendinopathy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Millar, Dr Neal
Authors: Millar, N.L., and Murrell, G.A.C.
Subjects:R Medicine > RD Surgery
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Mediators of Inflammation
Publisher:Hindawi Publishing Corporation
ISSN:0962-9351
ISSN (Online):1466-1861
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in Mediators of Inflammation 2012:436203
Publisher Policy:Reproduced under a Creative Commons License

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