The incidence of monoclonal gammopathy in a population over 45 years old determined by isoelectric focusing

Sinclair, D., Sheehan, T., Parrott, D.M.V. and Stott, D.I. (1986) The incidence of monoclonal gammopathy in a population over 45 years old determined by isoelectric focusing. British Journal of Haematology, 64(4), pp. 745-750. (doi: 10.1111/j.1365-2141.1986.tb02236.x)

Abstract

Immuno-isoelectric focusing (IIEF), a technique previously shown to be sensitive for the detection of paraproteinaemia, was used to test 200 individuals over the age of 45, without history of B cell neoplasm, for the presence of serum paraproteinaemia. 11% of these individuals had evidence of paraproteinaemia detectable by IIEF compared with only 2% by zonal and immunoelectrophoresis. A further 12% had oligoclonal immunoglobulins and the remainder had no qualitative abnormality of the immunoglobulin profile. These results are discussed with particular reference to the aetiology, diagnosis and monitoring of potential B cell neoplasm in high risk individuals or groups.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Stott I, Professor David
• Authors: Sinclair, D., Sheehan, T., Parrott, D.M.V., and Stott, D.I.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: British Journal of Haematology
• Publisher: Blackwell Publishing
• ISSN: 0007-1048
• Published Online: 07 July 2008