Quantitation of monoclonal immunoglobulins by immuno-isoelectric focusing and its application for monitoring secretory B cell neoplasia

Sinclair, D., Parrott, D.M.V. and Stott, D.I. (1986) Quantitation of monoclonal immunoglobulins by immuno-isoelectric focusing and its application for monitoring secretory B cell neoplasia. Journal of Immunological Methods, 90(2), pp. 247-255. (doi:10.1016/0022-1759(86)90082-7)

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Abstract

A scheme for quantitation of serum and urinary paraproteins is described using isoelectric focusing and scanning densitometry. Paraproteins could be quantified using this system when present at concentrations ranging from 1 mg/ml to 26 mg/ml, depending on the immunoglobulin class.

The relevance of these results to monitoring secretory B cell neoplasia andthe distinction between monoclonal gammopathy of undetermined significance and myeloma is discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott, Professor David
Authors: Sinclair, D., Parrott, D.M.V., and Stott, D.I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunological Methods
Publisher:Elsevier
ISSN:0022-1759

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