The incidence and possible relevance of Bence-Jones protein in the sera of patients with multiple myeloma

Sinclair, D., Dagg, J.H., Smith, J.G. and Stott, D.I. (1986) The incidence and possible relevance of Bence-Jones protein in the sera of patients with multiple myeloma. British Journal of Haematology, 62(4), pp. 689-694. (doi:10.1111/j.1365-2141.1986.tb04092.x)

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Abstract

We present results showing that the detectable incidence of Bence-Jones protein in the sera of patients with multiple myeloma is equivalent to the highest detectable incidence of Bence-Jones protein in highly concentrated urine when tested by immuno-isoelectric focusing. In a series of 25 multiple myeloma patients, immuno-isoelectric focusing showed the incidence of Bence-Jones proteinemia to be 68% compared with a detectable incidence of Bence-Jones proteinuria of 32-64% by immunoelectrophoresis and immuno-isoelectric focusing depending upon the urine concentration factor. In view of the variability of factors governing urinary Bence-Jones protein levels, such as renal catabolism, reabsorption and losses during concentration, we suggest that monitoring of serum Bence-Jones protein by immuno-isoelectric focusing should be carried out in conjunction with measurements of urinary Bence-Jones protein in multiple myeloma.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott, Professor David
Authors: Sinclair, D., Dagg, J.H., Smith, J.G., and Stott, D.I.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:British Journal of Haematology
Publisher:Blackwell Publishing
ISSN:0007-1048

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