Lectin binding to glycoproteins in the surface membrane of Schistosoma mansoni

MacGregor, A.N., Stott, D.I. and Kusel, J.R. (1985) Lectin binding to glycoproteins in the surface membrane of Schistosoma mansoni. Molecular and Biochemical Parasitology, 16(2), pp. 163-172. (doi:10.1016/0166-6851(85)90084-2)

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Abstract

A number of lectins were assessed for their ability to bind to glycoproteins in the surface membrane of Schistosoma mansoni. The membrane polypeptides were separated by SDS-PAGE and the glycoproteins visualised by incubating the gel with radio-iodinated lectin followed by autoradiography. Most of the individual lectins bound to a variety of glycoproteins but peanut agglutinin and Dolichos biflorus agglutinin bound preferentially to a single glycoprotein of apparent molecular weight 170 000. This glycoprotein was subsequently shown to be exposed at the surface of the parasite and localised at the tubercles.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Stott, Professor David
Authors: MacGregor, A.N., Stott, D.I., and Kusel, J.R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN:0166-6851

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