p53 mutation, deprivation and poor prognosis in primary breast cancer

Baker, L. et al. (2010) p53 mutation, deprivation and poor prognosis in primary breast cancer. British Journal of Cancer, 102(4), pp. 719-726. (doi: 10.1038/sj.bjc.6605540)

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Abstract

Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53 mutation might contribute to the impaired outcome observed in patients from deprived communities. methods: p53 mutation status was determined using the Roche Amplichip research test in 246 women with primary breast cancer attending a single cancer centre and related to deprivation, pathology, overall, and disease-free survival. results: p53 mutation, identified in 64/246 (26%) of cancers, was most common in 10 out of 17 (58.8%) of the lowest (10th) deprivation decile. Those patients with p53 mutation in the 10th decile had a significantly worse disease-free survival of only 20% at 5 years (Kaplan–Meier logrank χ2=6.050, P=0.014) and worse overall survival of 24% at 5 years (Kaplan–Meier logrank χ2=6.791, P=0.009) than women of deciles 1–9 with p53 mutation (c.f. 56% and 72%, respectively) or patients in the 10th decile with wild-type p53 (no disease relapse or deaths). conclusion: p53 mutation in breast cancer is associated with socio-economic deprivation and may provide a molecular basis, with therapeutic implications, for the poorer outcome in women from deprived communities.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mccowan, Professor Colin
Authors: Baker, L., Quinlan, P.R., Patten, N., Ashfield, A., Birse-Stewart-Bell, L.-J., Mccowan, C., Bourdon, J.-C., Purdie, C.A., Jordan, L.B., Dewar, J.A., Wu, L., and Thompson, A.M.
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:British Journal of Cancer
Publisher:Nature Publishing Group
ISSN:0007-0920
ISSN (Online):1532-1827
Published Online:26 January 2010
Copyright Holders:Copyright © 2010 Cancer Research UK
First Published:First published in British Journal of Cancer 102(4):719-726
Publisher Policy:Reproduced under a Creative Commons License

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