SaBer DBS: a fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation

Ewing, S.G., Porr, B., Riddell, J.S. , Winter, C. and Grace, A.A. (2013) SaBer DBS: a fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation. Journal of Neuroscience Methods, 213(2), pp. 228-235. (doi:10.1016/j.jneumeth.2012.12.008)

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Abstract

To effectively study the mechanisms by which deep brain stimulation (DBS) produces its therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS over an extended period of time in awake, freely behaving animals. To date multiple preclinical stimulators have been designed and described. However, these stimulators have failed to incorporate some of the design criteria necessary to provide a system analogous to those used clinically. Here we define these design criteria and propose an improved and complete preclinical DBS system. This system is fully programmable in frequency, pulse-width and current amplitude, has a rechargeable battery and delivers biphasic, charge-balanced output to two independent electrodes. The system has been optimized for either implantation or for use externally via attachment to rodent jackets.

Item Type:Articles
Keywords:Deep brain stimulation
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Porr, Dr Bernd and Riddell, Dr John
Authors: Ewing, S.G., Porr, B., Riddell, J.S., Winter, C., and Grace, A.A.
Subjects:Q Science > QP Physiology
T Technology > TK Electrical engineering. Electronics Nuclear engineering
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Neuroscience Methods
ISSN:0165-0270

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