Fungal biofilm resistance

Ramage, G. , Rajendran, R., Sherry, L. and Williams, C. (2012) Fungal biofilm resistance. International Journal of Microbiology, 2012(528521), (doi:10.1155/2012/528521)

Ramage, G. , Rajendran, R., Sherry, L. and Williams, C. (2012) Fungal biofilm resistance. International Journal of Microbiology, 2012(528521), (doi:10.1155/2012/528521)

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Abstract

Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon and Rajendran, Dr Ranjith and Sherry, Dr Leighann
Authors: Ramage, G., Rajendran, R., Sherry, L., and Williams, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:International Journal of Microbiology
Publisher:Hindawi Publishing
ISSN:1687-918X
ISSN (Online):1687-9198
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in International Journal of Microbiology 2012:528521
Publisher Policy:Reproduced under a Creative Commons License
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