Submaximal, but not maximal, exercise testing detects differences in the effects of beta-blockers during tredmill excerise: a study of Celiprolol and Atenolol

McLenachan, J.M., Grant, S., Ford, I. , Henderson, E. and Dargie, H.J. (1991) Submaximal, but not maximal, exercise testing detects differences in the effects of beta-blockers during tredmill excerise: a study of Celiprolol and Atenolol. American Heart Journal, 121(2), pp. 691-696.

Full text not currently available from Enlighten.

Abstract

Celiprolol is a new-generation beta-blocker with ancillary properties that include partial beta 2-agonism and direct vasodilating activity. The effects of atenolol and celiprolol on maximal exercise capacity and on both respiratory variables and subjective indices of breathlessness and fatigue during submaximal exercise were compared in a placebo-controlled crossover study of 12 trained volunteers. Both atenolol and celiprolol equally and significantly reduced exercise capacity and maximal oxygen consumption. During constant submaximal exercise at 70% maximal oxygen uptake, however, differences emerged between the two beta-blockers. Atenolol was associated with a significantly higher minute ventilation than placebo. In contrast, values for minute ventilation and respiratory exchange ratio with celiprolol were similar to values with placebo. During the early stages of exercise, treatment with atenolol was also associated with higher scores for the subjective indices of breathlessness and fatigue. Thus submaximal exercise, which may be physiologically more relevant to the everyday activities of patients, may demonstrate potentially useful differences between drugs that are not seen during maximal exercise testing.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dargie, Professor Henry and Ford, Professor Ian
Authors: McLenachan, J.M., Grant, S., Ford, I., Henderson, E., and Dargie, H.J.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:American Heart Journal
ISSN:0002-8703

University Staff: Request a correction | Enlighten Editors: Update this record