Interleukin-21 – a biomarker of importance in predicting myocardial function following acute infarction?

Weir, R. A.P., Miller, A. M., Petrie, C. J., Clements, S., Steedman, T., Dargie, H. J., Squire, I. B., Ng, L. L., McInnes, I. B. and McMurray, J. J.V. (2012) Interleukin-21 – a biomarker of importance in predicting myocardial function following acute infarction? Cytokine, 60(1), pp. 220-225. (doi:10.1016/j.cyto.2012.06.002) (PMID:22748465)

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Publisher's URL: http://dx.doi.org/10.1016/j.cyto.2012.06.002

Abstract

Introduction Following acute myocardial infarction (AMI), the acute inflammatory response contributes to wound healing but also to progressive myocardial injury. Interleukin-21 (IL-21) plays a key role in immunoregulation; whether IL-21 is associated with left ventricular (LV) remodelling after AMI is unknown.

Methods Plasma IL-21 concentrations were measured in 100 patients (age 58.9 ± 12.0 years, 77% male) admitted with AMI and LV dysfunction, at baseline (mean 46 h) and again at 24 weeks; cardiac magnetic resonance and measurement of B-type natriuretic peptide, monocyte chemoattractant protein-1, matrix metalloproteinase (MMP)-2, -3, -9, and tissue inhibitor of metalloproteinase (TIMP)-1, -2, -4 occurred at both time-points. Remodelling was defined as change in LV end-systolic volume index (ΔLVESVI).

Results Plasma IL-21 concentration was unchanged over time (48.1 [SD 35.4] pg/mL at baseline vs. 48.8 [61.3] pg/mL at 24 weeks, p = 0.92). Baseline IL-21 correlated significantly with ΔLVESVI (r = 0.30, p = 0.005) and change in LV end-diastolic volume index (r = 0.33, p = 0.003). On multivariate analysis, plasma IL-21 was an independent predictor of remodelling. IL-21 was also significantly associated with higher TIMP-4 concentrations and lower MMP-9 concentrations at baseline.

Conclusions IL-21 predicts adverse remodelling following AMI in patients with LV dysfunction. Whether it plays a direct pathophysiological role in remodelling merits further study.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Miller, Dr Ashley and Dargie, Professor Henry and McMurray, Professor John and Hopkins, Mrs Tracey
Authors: Weir, R. A.P., Miller, A. M., Petrie, C. J., Clements, S., Steedman, T., Dargie, H. J., Squire, I. B., Ng, L. L., McInnes, I. B., and McMurray, J. J.V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Cytokine
Publisher:Elsevier
ISSN:1043-4666
Published Online:27 June 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
483611Interleukin-33: A Novel Cytokine in the Inflammation of Atherosclerosis and ObesityAshley MillerBritish Heart Foundation (BHF)FS/08/035/25309III -IMMUNOLOGY
483612Interleukin-33: A Novel Cytokine in the Inflammation of Atherosclerosis and ObesityAshley MillerBritish Heart Foundation (BHF)FS/08/035/25309III -IMMUNOLOGY